Hyperpolarization-activated cyclic nucleotide-gated cation channel subtypes differentially modulate the excitability of murine small intestinal afferents

Figure 1 Effects of CsCl on the mechenosensory activity of small intestinal afferents. A: Original recording of the mesenteric afferent nerve activity in response to distension in an ex vivo jejunum preparation; B: The pressure-afferent nerve response curves in control and in the presence of hyperpolarization-activated cyclic nucleotide-gated cation blocker, 5 mmol/L CsCl; C: Bar graph showing the low- and high- threshold mechanosensory responses with or without the presence of 5 mmol/L CsCl. ^aP < 0.05.