A pharmacodynamic model of portal hypertension in isolated perfused rat liver

Table 2 Phenylephrine elevates portal pressure (mean ± SE, n_i = 4)

Log[PE (mol/L)]	d0	d2	d56	d84
-12	0.210 ± 0.19	0.013 ± 0.02	0.013 ± 0.02	0.019 ± 0.03
-11	0.260 ± 0.16	0.025 ± 0.03	0.017 ± 0.02	0.024 ± 0.04
-10	0.360 ± 0.18	0.044 ± 0.06	0.046 ± 0.06	0.047 ± 0.07
-9	0.420 ± 0.24	0.072 ± 0.09	0.182 ± 0.25	0.076 ± 0.09
-8	0.550 ± 0.37	0.090 ± 0.12	0.247 ± 0.27	0.119 ± 0.10
-7	0.520 ± 0.37	0.093 ± 0.12	0.269 ± 0.27	0.123 ± 0.11
-6	0.570 ± 0.24	0.113 ± 0.13	0.286 ± 0.28	0.138 ± 0.12

Primary data were used to calculate the dose-effect relationship between phenylephrine and portal vein constriction in the isolated portal perfused rat livers without chronic hepatitis, where rats were administered 3 mL/kg olive oil subcutaneously twice per week for 84 d (control rats) (d₀). Rats with chronic hepatitis at three stages, hepatic degeneration (d₂₈), fibrosis (d₅₆) and cirrhosis (d₈₄), were administered 3 mL/kg 40% (v/v) CCl₄ in olive oil subcutaneously twice per week for 28 d, 56 d and 84 d, respectively. PE: Phenylephrine.