c-Jun N-terminal kinase is required for thermotherapy-induced apoptosis in human gastric cancer cells

Figure 4 Expression of p-c-Jun N-terminal kinase, Bax, caspase-3 and Bcl-2 proteins in SGC-7901 cells with or without SP600125 treatment following thermotherapy for various time periods. A1, B2, C1, D1: Expression of p-JNK, Bax, caspase-3 and Bcl-2 proteins in SGC-7901 cells without SP600125 treatment; A2, B2, C2, D2: Expression of p-JNK, Bax, caspase-3 and Bcl-2 proteins in SGC-7901 cells with SP600125 treatment; A3, B3, C3, D3: Comparison of p-JNK, Bax, caspase-3 and Bcl-2 proteins in SGC-7901 cells with or without SP600125 treatment; Expression of p-JNK, Bax, caspase-3 proteins in SGC-7901 cells with SP600125 treatment was significantly inhibited compared with that in SGC-7901 cells without SP600125 treatment (^bP < 0.01); Bcl-2 protein did not show an obvious change in SGC-7901 cells with or without SP600125 treatment (P > 0.05). JNK: c-Jun N-terminal kinase.