Notch2 regulates matrix metallopeptidase 9 via PI3K/AKT signaling in human gastric carcinoma cell MKN-45

Figure 4 Knockdown of Notch2 enhanced the expression of matrix metallopeptidase 9 via increased phosphorylation of p-Akt in MKN-45 cells. A, B: Knockdown of Notch2 led to an increased phosphorylation of Akt (p-Akt); C, D: Blockade of PI3K/Akt pathway by LY294002 (20 μmol/L) abolished the effect of Notch small interfering RNA (siRNA) in Akt phosphorylation and matrix metallopeptidase 9 (MMP9). ^aP < 0.05 vs the all control groups. DMSO: Dimethyl sulfoxide.