Notch2 regulates matrix metallopeptidase 9 via PI3K/AKT signaling in human gastric carcinoma cell MKN-45

Figure 2 Knockdown of Notch2 led to an increased migration and invasion of MKN-45 cells. Cells were transfected with scrambled small interfering RNA (siRNA) (Scra, A, C) or Notch2 siRNA (B, D) for 48 h, and the effect of the migration (A, B, E) and invasion (C, D, F) were assayed as described in “Materials and Methods”. The number of migrated cells or invaded cells were quantitated (E, F). ^aP < 0.05 vs the Scra groups. A, B, ×200; C, D, ×400.