Mechanisms of cholecystokinin-induced calcium mobilization in gastric antral interstitial cells of Cajal

Figure 7 Effects of chelerythrine on Sulfated cholecystokinin-8-evoked Ca²⁺ signaling in interstitial cells of Cajal. Fluo-3-loaded interstitial cells of Cajal were pretreated with various concentrations of chelerythrine (A: 10 nmol/L; B: 100 nmol/L; C: 1 μmol/L; and D: 10 μmol/L) for 2 min before administration of cholecystokinin-8 (CCK-8S) (100 nmol/L). All could significantly increase the CCK-8S-evoked [Ca²⁺]i response; E: Quantification of [Ca²⁺]i changes shown in A-D. Each experiment was repeated at least three times. ^bP < 0.01 vs control.