Gardenia jasminoides attenuates hepatocellular injury and fibrosis in bile duct-ligated rats and human hepatic stellate cells

Figure 2 Biochemical and fibrotic gene expression in bile duct ligation rats. Gardenia jasminoides significantly improved liver function and reduced the expression of liver fibrosis marker genes from rats submitted to bile duct ligation (BDL) or sham-operated rats treated with vehicle or Gardenia jasminoides. A: Serum levels of alanine aminotransferase (ALT); B: Serum levels of aspartate aminotransferase (AST); C: Liver hydroxyproline content; D, E: Liver mRNA expression of transforming growth factor-β1 (TGF-β1) (D) and collagen type I(Col I) (E); F: Liver protein expression of α-smooth muscle actin (α-SMA) detected by Western blotting. ^bP < 0.01 vs sham; ^cP < 0.05, ^dP < 0.01 vs BDL + vehicle (n = 8).