Single nucleotide polymorphisms in the CDH17 gene of colorectal carcinoma

Table 2 The correlation between the genotype of CDH17 gene c.343A>G and clinicopathologic parameters in colorectal carcinomas n (%)

Clinicopathologic parameters	n	Genotype CDH17 c.343A>G			χ2	P value
		A/A	A/G	G/G
Gender
Male	47	10 (21.3)	25 (53.2)	12 (25.5)	2.236	0.327
Female	46	16 (34.8)	19 (41.3)	11 (23.9)
Age (yr)
< 50	29	10 (34.5)	15 (51.7)	4 (13.8)	2.854	0.240
≥ 50	64	16 (25)	29 (45.3)	19 (29.7)
Tumor location
Colon	32	8 (25.0)	16 (50.0)	8 (25.0)	0.229	0.892
Rectum	61	18 (29.5)	28 (45.9)	15 (24.6)
Tumor size (cm)
< 5	68	18 (26.5)	34 (50.0)	16 (23.5)	0.734	0.693
≥ 5	25	8 (32.0)	10 (40.0)	7 (28.0)
Macroscopic appearance
Protrude type	31	8 (25.8)	17 (54.8)	6 (19.4)	1.948	0.7451
Ulcer type	46	12 (26.1)	21 (45.7)	13 (28.3)
Infiltrating type	16	6 (37.5)	6 (37.5)	4 (25.0)
Colloid type	0	0 (0.0)	0 (0.0)	0 (0.0)
Histologic type
Adenocarcinoma	71	18 (25.4)	34 (47.9)	19 (26.8)	2.179	0.7031
Adenocarcinoma and mucinous carcinoma	9	4 (44.4)	3 (33.3)	2 (22.2)
Mucinous carcinoma	13	4 (30.8)	7 (53.8)	2 (15.4)
Undifferentiated carcinoma	0	0 (0.0)	0 (0.0)	0 (0.0)
Adenosquamous carcinoma	0	0 (0.0)	0 (0.0)	0 (0.0)
Squamous cell carcinoma	0	0 (0.0)	0 (0.0)	0 (0.0)
Invasion depth
Submucosa	2	0 (0.0)	2 (100.0)	0 (0.0)	0.696	0.7062
Muscular layer	34	12 (35.3)	15 (44.1)	7 (20.6)
Serous coat	48	12 (25)	21 (43.8)	15 (31.3)
Other organs	9	2 (22.2)	6 (66.7)	1 (11.1)
Differentiation degree
Well-differentiated	4	0 (0.0)	2 (50.0)	2 (50.0)	2.212	0.3312
Moderately-differentiated	63	17 (27.0)	33 (52.4)	13 (20.6)
Poorly-differentiated	26	9 (34.6)	9 (34.6)	8 (30.8)
Lymph node metastasis
No	59	16 (27.1)	35 (59.3)	8 (13.6)	13.105	0.0013
Yes	34	10 (29.4)	9 (26.5)	15 (44.1)
TNM grade
I	26	8 (30.8)	16 (61.5)	2 (7.7)	10.344	0.00623
II	31	7 (22.6)	18 (58.1)	6 (19.4)
III	33	9 (27.3)	9 (27.3)	15 (45.5)
IV	3	2 (66.7)	1 (33.3)	0 (0.0)
Hematogenous metastasis
No	90	24 (26.7)	43 (47.8)	23 (25.6)	2.556	0.2791
Yes	3	2 (66.7)	1 (33.3)	0 (0.0)
Recurrence
No	91	24 (26.4)	44 (48.4)	23 (25.3)	5.267	0.0721
Yes	2	2 (100.0)	0 (0.0)	0 (0.0)

¹The Fisher’s Exact Test;

²The Kruskal-Wallis Test;

³Statistically significant.