Comparative genomic study of gastric epithelial cells co-cultured with Helicobacter pylori

Table 4 Most differentially expressed genes in GES-1 cells co-cultured with the most virulent gastric carcinoma-derived strain vs the least virulent chronic gastritis-derived strain

Gene name	Betweenness centrality	Description	Identified or proposed function
JUN	0.201780	Jun oncogene	Cell growth and/or maintenance, signal transduction molecules, and transcription factors
KRAS	0.185944	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	Regulation of cell cycle, cell growth and/or maintenance
BRCA1	0.162070	Breast cancer 1, early onset	DNA damage checkpoint; p53/ATM signaling, and induction of apoptosis
SMAD2	0.121460	SMAD family member 2	Transcription factors
TRAF1	0.092496	Tumor necrosis factor receptor-associated factor 1	DNA damage checkpoint, p53/NF-KB signaling, and cell cycle control
HDAC6	0.092239	Histone deacetylase 6	Cell proliferation and tumor angiogenesis