Diagnostic and therapeutic progress of multi-drug resistance with anti-HBV nucleos(t)ide analogues

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Dec 28, 2012 (publication date) through Jan 21, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Dec 28, 2012; 18(48): 7149-7157
Published online Dec 28, 2012. doi: 10.3748/wjg.v18.i48.7149

Table 3 Management of antiviral-resistant hepatitis B virus in updated guidelines

	AASLD 2009[27]	EASL 2012[101]
LAM-resistance	Add ADV or TDF	Switch to TDF or add ADV
	In patients with no prior exposure to other NA: Add LAM or ETV	In patients with no prior exposure to other NA: Switch to ETV or TDF
ADV-resistance	In patients with prior LAM resistance: Switch to TDF plus LAM or ETV	In patients with prior LAM resistance: Switch to TDF and another NA
ETV-resistance	Switch to TDF	Switch to or add TDF
TDF-resistance	--	In patients with no prior exposure to LAM: Switch to ETV
		In patients with prior LAM resistance: Add ETV

LAM: Lamivudine; LdT: Telbivudine; ETV: Entecavir; TDF: Tenofovir; ADV: Adefovir; NA: Nucleos(t)ide analogues.

Citation: Song ZL, Cui YJ, Zheng WP, Teng DH, Zheng H. Diagnostic and therapeutic progress of multi-drug resistance with anti-HBV nucleos(t)ide analogues. World J Gastroenterol 2012; 18(48): 7149-7157
URL: https://www.wjgnet.com/1007-9327/full/v18/i48/7149.htm
DOI: https://dx.doi.org/10.3748/wjg.v18.i48.7149