Diagnostic and therapeutic progress of multi-drug resistance with anti-HBV nucleos(t)ide analogues

doi:10.3748/wjg.v18.i48.7149

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World Journal of Gastroenterology

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1007-9327

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World J Gastroenterol. Dec 28, 2012; 18(48): 7149-7157
Published online Dec 28, 2012. doi: 10.3748/wjg.v18.i48.7149

Table 2 Patterns and pathways of antiviral drug resistance in chronic hepatitis B in the context of cross-resistance[99]

Pathway	Amino acid substitution in the rt domain	LAM	LdT	ETV	ADV	TDF
	WT	S	S	S	S	S
L-nucleoside (LAM/LdT)	M204I/V	R	R	I	S	S
Acyclic phosphonate (ADV)	N236T	S	S	S	R	I
Shared (LAM, LdT, ADV)	A181T/V	R	R	S	R	I
Double(ADV, TDF)	A181T/V + N236T	R	R	S	R	R
D-Cyclopentane (ETV)	L180M + M204V/I ± I169 ± T184 ± S202 ± M250	R	R	R	S	S

I: Intermediate sensitivity; R: Resistant; S: Sensitive based on cell culture and clinical; LAM: Lamivudine; LdT: Telbivudine; ETV: Entecavir; TDF: Tenofovir; ADV: Adefovir.

Citation: Song ZL, Cui YJ, Zheng WP, Teng DH, Zheng H. Diagnostic and therapeutic progress of multi-drug resistance with anti-HBV nucleos(t)ide analogues. World J Gastroenterol 2012; 18(48): 7149-7157
URL: https://www.wjgnet.com/1007-9327/full/v18/i48/7149.htm
DOI: https://dx.doi.org/10.3748/wjg.v18.i48.7149