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©2012 Baishideng Publishing Group Co.
World J Gastroenterol. Dec 28, 2012; 18(48): 7141-7148
Published online Dec 28, 2012. doi: 10.3748/wjg.v18.i48.7141
Published online Dec 28, 2012. doi: 10.3748/wjg.v18.i48.7141
Table 3 The characteristics of primary biliary cirrhosis murine models and primary biliary cirrhosis patients
| NOD.c3c4[50] | dnTGF-βR II[59] | IL-2Rα(-/-)[58,85] | Ae2a,b(-/-)[86] | 2OA-BSA induced[87] | Human | |
| Disease onset | 8-20 wk | 4 wk | 4 wk | 6 mo? | 4-12 wk | 40-60 yr |
| AMA | 56% | 100% | 100% | 40-80% | 100% | 95% |
| ANA | 80%-90% | (-) | 80% | (-) | ? | 30% |
| Cytokines | Th1 ↑ | Th1 ↑ | Th1, Th17 ↑ | Th1 ↑ | Th1 ↑ | Th1, Th17 ↑ |
| Treg cells | ↓ | ↓ | ↓ | ↓ | ↓ | ↓ |
| Ig | IgG, IgM ↑ | IgA ↑ | IgG, IgA ↑ | IgG, IgM ↑ | ? | IgM ↑ |
| Liver inflammation | ||||||
| CD8+/CD4+T | ↑ | ↑ | ↑ | ↑ | ↑ | ↑ |
| Treg | ? | ↓ | ↓ | ↓ | ? | ↑ |
| Fibrosis | ? | Slight | ? | Slight | Slight | Evident in late stage |
| Complication | Bile cyst and | Colitis | Colitis | ? | ? | Thyroid disorder |
| Extrahepatic damage | Anemia | Sjogren syndrome | ||||
- Citation: Shi TY, Zhang FC. Role of autoimmunity in primary biliary cirrhosis. World J Gastroenterol 2012; 18(48): 7141-7148
- URL: https://www.wjgnet.com/1007-9327/full/v18/i48/7141.htm
- DOI: https://dx.doi.org/10.3748/wjg.v18.i48.7141