Role of autoimmunity in primary biliary cirrhosis

Table 1 The characteristics of antinuclear antibodies in primary biliary cirrhosis patients

Staining pattern	Autoantigen	Prevalence (%)	Clinical significance
Nuclear dot	SP100[20,28]	25	Highly specific for PBC; Urinary tract infections
	PML[21,28]	19	Highly specific for PBC; Coexistence with anti-sp100
	SP140[22]	15	Coexistence with anti-sp100 and anti-PML
Nuclear periphery	gp210[23]	25	Association with disease severity and poor prognosis
(Nuclear pore complex)	p62[24]	30-55	Association with disease severity and poor prognosis
Nuclear periphery	Lamin[25]	6-8	Not highly specific for PBC
(Nuclear envelope)	LBR[24]	2-6	Highly specific for PBC
Anticentromere	Centromere[26]	30	Association with portal hypertension
?	AchR M3[27]	83	Unknown

PBC: Primary biliary cirrhosis; PML: Promyelocytic leukemia; LBR: Lamin B receptor.