Associations between interleukin-1 polymorphisms and gastric cancers among three ethnicities

doi:10.3748/wjg.v18.i47.7093

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World Journal of Gastroenterology

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1007-9327

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World J Gastroenterol. Dec 21, 2012; 18(47): 7093-7099
Published online Dec 21, 2012. doi: 10.3748/wjg.v18.i47.7093

Table 4 Genotype distributions of the interleukin-1B-31, interleukin-1B-511 and interleukin-1RN polymorphisms among different subtypes of gastric cancer in patients from the Tibet, Hui and Han ethnicities n (%)

	Tibet							Hui							Han
Genetype	Intestinal cases			Diffuse cases			Intestinal cases			Diffuse cases			Intestinal cases			Diffuse cases
	Controls	Cases	OR (95%CI)¹	P value	Cases	OR (95%CI)¹	P value	Controls	Cases	OR (95%CI)¹	P value	Cases	OR (95%CI)¹	P value	Controls	Cases	OR (95%CI)¹	P value	Cases	OR (95%CI)¹	P value
IL-1B-31
TT	47 (22.38)	16 (14.68)	1		7 (15.22)	1		59 (28.78)	33 (32.29)	1		13 (25.00)	1		65 (32.18)	28 (20.14)	1		12 (20.69)	1
CT	112 (53.33)	56 (51.38)	1.46 (0.75-2.84)	0.271	25 (54.35)	1.48 (0.59-3.70)	0.407	105 (51.22)	51 (48.11)	0.87 (0.49-1.54)	0.618	28 (53.85)	1.11 (0.51-2.39)	0.792	98 (48.52)	70 (50.36)	1.68 (0.97-2.90)	0.067	32 (55.17)	2.00 (0.82-4.88)	0.126
CC	51 (24.29)	37 (33.94)	2.17 (1.05-4.51)	0.037	14 (30.43)	1.86 (0.68-5.09)	0.228	41 (20.00)	22 (21.28)	0.93 (0.46-1.90)	0.845	11 (21.15)	1.18 (0.46-3.01)	0.734	39 (19.31)	41 (29.50)	2.51 (1.32-4.76)	0.005	14 (24.14)	1.79 (0.85-3.77)	0.126
IL-1B-511
CC	55 (26.19)	22 (20.18)	1		12 (25.53)	1		43 (20.98)	23 (21.70)	1		10 (19.23)	1		65 (32.17)	16 (11.51)	1		15 (25.86)	1
CT	93 (44.29)	54 (49.54)	1.48 (0.76-2.60)	0.277	26 (55.32)	1.28 (0.59-2.79)	0.535	110 (53.66)	58 (54.72)	1.00 (0.53-1.89)	0.998	30 (57.69)	1.13 (0.48-2.62)	0.784	99 (49.09)	69 (49.64)	2.74 (1.44-5.22)	0.002	32 (55.17)	1.45 (0.72-2.93)	0.301
TT	62 (29.52)	33 (30.28)	1.25 (0.64-2.42)	0.518	9 (19.15)	0.62 (0.24-1.63)	0.336	52 (25.37)	25 (23.58)	0.91 (0.43-1.92)	0.811	12 (23.08)	0.92 (0.34-2.50)	0.872	38 (18.81)	54 (38.85)	5.66 (2.82-11.33)	0	11 (18.97)	1.23 (0.50-3.02)	0.645
IL-1RN
L/L	185 (88.10)	93 (83.22)	1		36 (84.78)	1		156 (76.10)	64 (60.38)	1		30 (57.69)	1		171 (84.66)	116 (83.45)	1		50 (86.21)	1
2/L	25 (11.90)	16 (14.68)	1.32 (0.66-2.66)	0.439	10 (16.78)	1.87 (0.79-4.43)	0.158	49 (23.90)	42 (39.62)	2.08 (1.22-3.56)	0.007	22 (42.31)	2.31 (1.17-4.56)	0.016	31 (14.44)	23 (16.55)	1.09 (0.59-1.97)	0.807	8 (13.79)	1.02 (0.43-2.39)	0.971

¹Adjusted for age, sex, smoking status and Helicobacter pylori infection. IL: Interleukin; OR: Odds ratio.

Citation: Zhao JD, Geng PL, Li ZQ, Cui S, Zhao JH, Wang LJ, Li JZ, Ji FX, Li GY, Shen GS, Lin MZ, Shen CF, Cao CZ. Associations between interleukin-1 polymorphisms and gastric cancers among three ethnicities. World J Gastroenterol 2012; 18(47): 7093-7099
URL: https://www.wjgnet.com/1007-9327/full/v18/i47/7093.htm
DOI: https://dx.doi.org/10.3748/wjg.v18.i47.7093