Treatment strategies using adefovir dipivoxil for individuals with lamivudine-resistant chronic hepatitis B

doi:10.3748/wjg.v18.i47.6987

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Dec 21, 2012 (publication date) through Feb 2, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Dec 21, 2012; 18(47): 6987-6995
Published online Dec 21, 2012. doi: 10.3748/wjg.v18.i47.6987

Table 4 Patterns of genotypic resistance to adefovir dipivoxil in patients with lamivudine-resistant chronic hepatitis B

Mutation pattern	"Switch/combination" group¹ (n = 75)	"Add-on" group²(n = 79)
rtA181V	2	0
rtA181T	3	1
rtA181V + rtA181T	0	1
rtN236T	3	0
rtA181V + rtN236T	1	0
rtA181T + rtN236T	1	0
Total, n (%)	10 (13.3)	2 (2.5)

rtA181V, alanine to valine substitution at rt181; rtA181T, alanine to threonine substitution at rt181; rtN236T, asparagine to threonine substitution at rt236.

¹Lamivudine was first switched to adefovir dipivoxil (adefovir), and then lamivudine was re-added later as needed in case of primary non-response, inadequate response, or virologic breakthrough;

²Adefovir was added to ongoing lamivudine treatment due to lamivudine resistance.

Citation: Yun TJ, Jung JY, Kim CH, Um SH, An H, Seo YS, Kim JD, Yim HJ, Keum B, Kim YS, Jeen YT, Lee HS, Chun HJ, Kim CD, Ryu HS. Treatment strategies using adefovir dipivoxil for individuals with lamivudine-resistant chronic hepatitis B. World J Gastroenterol 2012; 18(47): 6987-6995
URL: https://www.wjgnet.com/1007-9327/full/v18/i47/6987.htm
DOI: https://dx.doi.org/10.3748/wjg.v18.i47.6987