Sex-dimorphic adverse drug reactions to immune suppressive agents in inflammatory bowel disease

Table 2 Categories of adverse drug reactions to immunosuppressive agents in general and stratified by sex n (%)

	Thiopurines	Thiopurines1,2	Methotrexate	Methotrexate1,2
Myelosuppression	33 (6)	12 (36)	NA	NA
Hepatotoxicity	33 (6)	19 (58)	10 (6)	6 (60)
Pancreatitis	10 (2)	2 (20)	NA	NA
Gastro-intestinal side-effects	23 (4)	8 (35)	10 (6)	6 (60)
Arthralgia and/or myalgia	11 (2)	5 (45)	2 (1)	1 (50)
Cutaneous side-effects	10 (2)	4 (40)	3 (2)	3 (100)
Infectious	6 (1)	3 (50)	2 (1)	1 (50)
Others3	23 (4)	7 (30)	13 (7)	2 (15)
Not specified4	6 (1)	3 (50)	4 (2)	1 (25)

¹No significant difference observed between males and females for none of the ADRs as tested with two-sided χ² test² Number and percentage of males in the group of patients with adverse drug reactions (ADR) to thiopurines;

³Number of all the people treated with the medicine;

⁴Headache, paresthesia, hair loss, fatigue, emotional instability, malaise; specific for methotrexate-injection site reaction. NA: Not available.