Sex-dimorphic adverse drug reactions to immune suppressive agents in inflammatory bowel disease

Table 1 Demographic characteristics and the use of medication (n = 843)

	Males1n (%)	Females1	P value2
Males/females (%males)	386 (46)	457
Age (mean, range), yr	43 (16-87)	42 (18-87)	0.138
Duration of the disease (mean, range)	14 (0-48)	14 (0-54)	0.168
CD/UC/unclassified	233 (40)/141 (58)/12 (57)	345/103/9	< 0.0001
Immunosuppressive agents	265 (45)	321	0.652
Thiopurines	247 (45)	299	0.665
Methotrexate	73 (42)	103	0.203
Cyclosporine	26 (57)	20	0.170
Tacrolimus	0	1
Anti-TNF	101 (42)	139	0.193
Infliximab	93 (41)	134	0.102
Adalimumab	39 (41)	60	0.328
Certolizumab	1 (20)	4	0.401

¹For each categorical variable number and percentage of males within the group is displayed; ²Pvalues for test of the sex-related differences; two-sidedχ²test for categorical variables andt-test for continuous variables. Anti-TNF: Anti-tumor necrosis factor agents; CD: Crohn’s disease; UC: Ulcerative colitis.