Tumor budding as a potential histopathological biomarker in colorectal cancer: Hype or hope?

Figure 1 Colorectal cancer at the invasive front shows different growth patterns. Tumor budding denotes the presence of isolated single neoplastic cells or small clusters of cells scattered in the stromal compartment at the invasive tumor margin (A), although intra-tumoral budding is also reported. Tumor margin organized in larger tumor cell clusters (B) and a smooth infiltration tumor margin (C). Hematoxylin and eosin stain, objective magnification 20×.