Meta-analysis of laparoscopic vs open liver resection for hepatocellular carcinoma

Table 3 Results of meta-analysis comparing laparoscopic vs open hepatectomy (only high-quality studies)

Outcome of interest	No. of studies	No. of patients	OR/WMD	95%CI	P value	Heterogeneity P value	I2(%)
Operative outcomes
Operation time (min)	6	354	4.69	-22.62, 32.00	0.74	0.0002	79
Intraoperative blood loss (mL)	6	333	-129.48	-224.76, -34.21	0.008	0.01	67
Blood transfusions requirement	7	416	0.49	0.26, 0.91	0.02	0.89	0
Postoperative outcomes
Liver failure	2	116	0.15	0.02, 0.95	0.04	1.00	0
Cirrhotic decompensation/ascites	7	416	0.32	0.16, 0.61	0.001	0.95	0
Bile leakage	3	205	0.55	0.10, 3.12	0.50	0.86	0
Postoperative bleeding	5	287	0.54	0.20, 1.45	0.22	0.83	0
Pulmonary complications	6	384	0.43	0.18, 1.04	0.06	0.46	0
Intra-abdominal abscess	2	101	0.21	0.01, 4.53	0.32	-	-
Mortality	8	474	0.46	0.14, 1.51	0.20	0.64	0
Hospital stay	6	333	-3.19	-4.09, -2.28	< 0.00001	0.91	0
Oncologic outcomes
Surgery margin positive rate	5	287	0.59	0.21, 1.62	0.31	0.65	0
Tumor recurrence	7	416	0.95	0.62, 1.46	0.81	0.93	0

WMD: Weighted mean difference; OR: Odds ratio.