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©2012 Baishideng Publishing Group Co.
World J Gastroenterol. Dec 7, 2012; 18(45): 6635-6644
Published online Dec 7, 2012. doi: 10.3748/wjg.v18.i45.6635
Published online Dec 7, 2012. doi: 10.3748/wjg.v18.i45.6635
Table 3 Association of UDP-glucuronosyltransferase1A1 genotypes with toxicity
Genotypes | Delayed diarrhea | Neutropenia | ||||||||||
Grades 2-4 | Grades 3/4 | Grades 3/4 | Grade 4 | |||||||||
n (%) | P value1 | P value2 | n (%) | P value1 | P value2 | n (%) | P value1 | P value2 | n (%) | P value1 | P value2 | |
UGT1A1*28 | ||||||||||||
TA 6/6 | 25 (27.8) | < 0.0005 | < 0.0005 | 14 (15.6) | 0.228 | 0.178 | 23 (25.6) | 0.088 | 0.055 | 7 (7.8) | 0.043 | 0.017 |
TA 6/7 | 2 (37.5) | 6 (18.8) | 10 (31.3) | 2 (6.3) | ||||||||
TA 7/7 | 8 (100) | 3 (37.5) | 5 (62.5) | 3 (37.5) | ||||||||
UGT1A1*6 | ||||||||||||
G/G | 24 (31.2) | 0.564 | 0.346 | 10 (13) | 0.12 | 0.057 | 23 (29.9) | 1 | 0.748 | 8 (10.4) | 0.857 | 0.473 |
A/G | 19 (39.6) | 11 (22.9) | 14 (29.2) | 4 (8.3) | ||||||||
A/A | 2 (40) | 2 (40) | 1 (20) | 0 (0) |
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Citation: Wang Y, Shen L, Xu N, Wang JW, Jiao SC, Liu ZY, Xu JM.
UGT1A1 predicts outcome in colorectal cancer treated with irinotecan and fluorouracil. World J Gastroenterol 2012; 18(45): 6635-6644 - URL: https://www.wjgnet.com/1007-9327/full/v18/i45/6635.htm
- DOI: https://dx.doi.org/10.3748/wjg.v18.i45.6635