UGT1A1 predicts outcome in colorectal cancer treated with irinotecan and fluorouracil

Table 3 Association of UDP-glucuronosyltransferase1A1 genotypes with toxicity

Genotypes	Delayed diarrhea						Neutropenia
	Grades 2-4			Grades 3/4			Grades 3/4			Grade 4
	n (%)	P value1	P value2	n (%)	P value1	P value2	n (%)	P value1	P value2	n (%)	P value1	P value2
UGT1A1*28
TA 6/6	25 (27.8)	< 0.0005	< 0.0005	14 (15.6)	0.228	0.178	23 (25.6)	0.088	0.055	7 (7.8)	0.043	0.017
TA 6/7	2 (37.5)			6 (18.8)			10 (31.3)			2 (6.3)
TA 7/7	8 (100)			3 (37.5)			5 (62.5)			3 (37.5)
UGT1A1*6
G/G	24 (31.2)	0.564	0.346	10 (13)	0.12	0.057	23 (29.9)	1	0.748	8 (10.4)	0.857	0.473
A/G	19 (39.6)			11 (22.9)			14 (29.2)			4 (8.3)
A/A	2 (40)			2 (40)			1 (20)			0 (0)

¹Fisher’s exact test for all genotype;

²Exact test of Cochran-Armitage trend test across genotypes. Toxicity grade by National Cancer Institute Common Toxicity Criteria version 3.0. A total of 130 patients were assessable for toxicity. Significant differences were found on grades 2-4 delayed diarrhea and grade 4 neutropenia for UGT1A1*28 genotypes. UGT1A1: UDP-glucuronosyltransferase1A1.