UGT1A1 predicts outcome in colorectal cancer treated with irinotecan and fluorouracil

doi:10.3748/wjg.v18.i45.6635

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Dec 7, 2012 (publication date) through Nov 4, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Dec 7, 2012; 18(45): 6635-6644
Published online Dec 7, 2012. doi: 10.3748/wjg.v18.i45.6635

Table 2 Association of UDP-glucuronosyltransferase1A1 in combination with thymidylate synthetase genotypes with tumor response

*UGT1A128**	TS promoter
*UGT1A128**	3RG/3RG	3RG/3RC, 3RG/2RG	3RC/3RC, 3RC/2RG, 2RG/2RG
TA6/6	2/11 (18.1)	4/13 (30.8)	6/44 (13.6)
TA6/7	1/4 (25)	1/6 (16.7)	5/15 (33.3)
TA7/7	0/2 (0)	0/2 (0)	1/3 (33.3)

Tumor response including complete and partial response, 111 patients were assessable for tumor response, no significant difference was found (Fisher’s exact test). UGT1A1: UDP-glucuronosyltransferase1A1; TS: Thymidylate synthetase.

Citation: Wang Y, Shen L, Xu N, Wang JW, Jiao SC, Liu ZY, Xu JM. UGT1A1 predicts outcome in colorectal cancer treated with irinotecan and fluorouracil. World J Gastroenterol 2012; 18(45): 6635-6644
URL: https://www.wjgnet.com/1007-9327/full/v18/i45/6635.htm
DOI: https://dx.doi.org/10.3748/wjg.v18.i45.6635