UGT1A1 predicts outcome in colorectal cancer treated with irinotecan and fluorouracil

doi:10.3748/wjg.v18.i45.6635

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Dec 7, 2012; 18(45): 6635-6644
Published online Dec 7, 2012. doi: 10.3748/wjg.v18.i45.6635

Table 1 Association of UDP-glucuronosyltransferase1A1 and thymidylate synthetase genotypes with tumor response

Genotypes	Tumor response
Genotypes	n (%)	P value¹
UGT1A1*28
TA 6/6	14 (17.9)	0.446
TA 6/7, TA 7/7	8 (24.2)
UGT1A1*6
G/G	11 (15.7)	0.217
G/A, A/A	11 (26.8)
TS promotor
3RG/3RG	3 (17.6)	0.880
3RG/3RC, 3RG/2RG	5 (23.8)
3RC/3RC, 3RC/2RG, 2RG/2RG	12 (19.4)

¹Fisher’s exact test for all genotypes. Tumor response including complete and partial response, 111 patients were assessable for tumor response. UGT1A1: UDP-glucuronosyltransferase1A1; TS: Thymidylate synthetase.

Citation: Wang Y, Shen L, Xu N, Wang JW, Jiao SC, Liu ZY, Xu JM. UGT1A1 predicts outcome in colorectal cancer treated with irinotecan and fluorouracil. World J Gastroenterol 2012; 18(45): 6635-6644
URL: https://www.wjgnet.com/1007-9327/full/v18/i45/6635.htm
DOI: https://dx.doi.org/10.3748/wjg.v18.i45.6635