Novel ATP8B1 mutation in an adult male with progressive familial intrahepatic cholestasis

Figure 1 Histological features of samples taken at age 10 and current liver biopsy specimens (age 23 years). A: Multinucleated giant cells (black arrow) and ductal cholestasis (white arrow) in the previously sampled liver tissue (image, × 400); B: Ductal cholestasis (white arrow) and ballooning degeneration of the hepatocytes (black arrow) in the previously sampled liver tissue (image, × 200); C: Ductal cholestasis and hepatocytes ballooning degeneration (black arrow) in the recently sampled liver tissue (image, × 200); D: Mild portal and lobular fibrosis in the previously sampled liver tissue (image, × 200); E: Moderate lobular fibrosis in the recently sampled liver tissue (image, × 200); F: Moderate portal fibrosis in the recently sampled liver tissue (image, × 200).