Clonal evolution of hepatitis B virus polymerase gene mutations during lamivudine-adefovir combination treatment

Figure 1 Evolution of antiviral mutations in hepatitis B virus polymerase based on the clonal analysis of serial samples in patients. A: Patient 1; B: Patient 2; C: Patient 3; D: Patient 4. The boxes and capital letters denote the domains of the hepatitis B virus polymerase gene. ADV: Adefovir; LMV: Lamivudine; RT: Reverse transcriptase.