Glucose-responsive artificial promoter-mediated insulin gene transfer improves glucose control in diabetic mice

Figure 4 rAd-SP-rINSfur administration preserves endogenous islets in Lepr^db/db mice. Pancreatic samples were obtained from rAd-CMV-βgal and rAd-SP-rINSfur virus-treated animals on day 50 after virus injection. Tissue sections were prepared and stained with hematoxylin and eosin (HE) or stained with anti-insulin antibody. (A) is 20 × and (B) is 40 × magnification.