Glucose-responsive artificial promoter-mediated insulin gene transfer improves glucose control in diabetic mice

Figure 3 rAd-SP-rINSfur administration improves insulin tolerance in Lepr^db/db mice. Insulin (1.5 U/kg body weight, ip) was administered to mice injected with rAd-CMV-βgal or rAd-SP-rINSfur at 5 wk after virus injection (n = 4-6), and blood glucose levels were measured. The area under the curve (AUC) for each insulin tolerance test was quantified. All values are mean ± SE. ^aP < 0.05 vs rAd-CMV-βgal group.