Glucose-responsive artificial promoter-mediated insulin gene transfer improves glucose control in diabetic mice

Figure 2 rAd-SP-rINSfur administration improves glucose tolerance in Lepr^db/db mice. Glucose (2 g/kg body weight) was administered by intraperitoneal injection, and blood glucose levels were measured at (A) 4 wk and (B) 6 wk (n = 4-6) after virus injection. The area under the curve (AUC) for each glucose tolerance test was quantified. All values are mean ± SE. ^bP < 0.01 vs rAd-CMV-βgal group.