Intestinal mucosal atrophy and adaptation

doi:10.3748/wjg.v18.i44.6357

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Nov 28, 2012 (publication date) through Dec 25, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Nov 28, 2012; 18(44): 6357-6375
Published online Nov 28, 2012. doi: 10.3748/wjg.v18.i44.6357

Table 3 Potential pharmacotherapy targets for intestinal failure

Dose mg/kg per d		Side effects	Structure	Approval
Growth hormone	0.1	Fluid retention, joint pain, hyperglycemia	191-amino acid protein	FDA
EGF	NA¹	NA	53-amino acid peptide	Not available commercially
GLP-2	0.1	Abdominal pain/obstructive symptoms	dpp-IV resistant 33-amino acid peptide	Phase III clinical trials available in Europe

¹Dose not specified for human use. FDA: Food and Drug Administration; GLP-2: Glucagon-like peptide-2; EGF: Epidermal growth factor; dpp-IV: Dipeptidyl peptidase IV; NA: Not available.

Citation: Shaw D, Gohil K, Basson MD. Intestinal mucosal atrophy and adaptation. World J Gastroenterol 2012; 18(44): 6357-6375
URL: https://www.wjgnet.com/1007-9327/full/v18/i44/6357.htm
DOI: https://dx.doi.org/10.3748/wjg.v18.i44.6357