MicroRNAs in biliary diseases

doi:10.3748/wjg.v18.i43.6189

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Nov 21, 2012 (publication date) through Jul 25, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Nov 21, 2012; 18(43): 6189-6196
Published online Nov 21, 2012. doi: 10.3748/wjg.v18.i43.6189

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Figure 2 Role of miRNA-506 in the etiopathogenesis of primary biliary cirrhosis. Different risk factors could induce genetic alterations leading to anion exchange 2 (AE2) downregulation in primary biliary cirrhosis (PBC) cholangiocytes. miRNA-506 is overexpressed in PBC cholangiocytes, thus resulting in the inhibition of both AE2 protein translation and subsequent Cl^-/HCO₃^- activity, and impairing the biliary secretory functions.

Citation: Munoz-Garrido P, Fernandez-Barrena MG, Hijona E, Carracedo M, Marín JJG, Bujanda L, Banales JM. MicroRNAs in biliary diseases. World J Gastroenterol 2012; 18(43): 6189-6196
URL: https://www.wjgnet.com/1007-9327/full/v18/i43/6189.htm
DOI: https://dx.doi.org/10.3748/wjg.v18.i43.6189