MicroRNAs in biliary diseases

doi:10.3748/wjg.v18.i43.6189

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Nov 21, 2012 (publication date) through Dec 24, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Nov 21, 2012; 18(43): 6189-6196
Published online Nov 21, 2012. doi: 10.3748/wjg.v18.i43.6189

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Figure 1 miRNA-15a/Cdc25a interplay participates in hepatic cystogenesis of polycystic liver diseases. miRNA-15a directly targets the cell cycle regulator Cdc25a. In polycystic rat and human cholangiocytes, miR15a is downregulated, thus resulting in Cdc25a upregulation, cell proliferation and cystogenesis. The Cdc25a inhibitor vitamin K3 was demonstrated to target Cdc25a, blocking the hepatorenal cystogenesis of several rodent models of polycystic kidney and liver disease. This suggests the therapeutic potential of vitamin K3 for polycystic kidney and liver diseases.

Citation: Munoz-Garrido P, Fernandez-Barrena MG, Hijona E, Carracedo M, Marín JJG, Bujanda L, Banales JM. MicroRNAs in biliary diseases. World J Gastroenterol 2012; 18(43): 6189-6196
URL: https://www.wjgnet.com/1007-9327/full/v18/i43/6189.htm
DOI: https://dx.doi.org/10.3748/wjg.v18.i43.6189