Galactosylated chitosan/5-fluorouracil nanoparticles inhibit mouse hepatic cancer growth and its side effects

Figure 8 The activity of cytotoxicity T lymphocyte and natural killer cell was detected by 3-(4, 5-dimethylthiazd-2-yl)-2,5-diphenyltentrazolium bromide in the orthotopic transplant model of hepatocellular carcinoma. The cytotoxic activities of cytotoxicity T lymphocyte (CTL) and natural killer (NK) cells were significantly decreased in 5-fluorouracil (5-FU) group compared with other three groups (P < 0.01), while, the crosscurrent was found in galactosylated chitosan (GC) group compared with 5-FU group (P < 0.05). ^aP < 0.05, ^bP < 0.01 vs control group; ^dP < 0.01 vs 5-FU group.