PNPLA3, the triacylglycerol synthesis/hydrolysis/storage dilemma, and nonalcoholic fatty liver disease

Figure 4 Linkage disequilibrium plot across the patatin-like phospholipase domain containing 3 gene. The horizontal white line depicts the DNA segment of chromosome 22q13.31. The rs738409 location is highlighted in a black ellipse. An LD plot is depicted in the bottom part of the figure: each diamond represents the magnitude of LD for a single pair of markers, with colors indicating strong LD (red r² = 1.0) and no LD (white, r^r = 0) as the extremes (different red tones indicate intermediate LD). Numbers inside the diamonds stand for r² values. Haplotype analysis of PNPLA3 shows that the rs738409 is in moderate LD (no more than r²: 0.65) with other variants. Plot was obtained by the software Haploview 2.0 freely available at http://www.broad.mit.edu/mpg/haploview/. LD: Linkage disequilibrium; PNPLA3: Patatin-like phospholipase domain containing 3.