Characteristics of deslanoside-induced modulation on jejunal contractility

Figure 1 Deslanoside-induced bidirectional regulation on the contractility of jejunal smooth muscle fragment. A: Dose response relationship of caslano side; B, D: Representative traces and statistical analysis of total traces from six independent experiments of deslanoside-induced bidirectional regulation on the contractility of jejunal smooth muscle fragment (JSMF) in eight low contractile states (LCS); C, E: Representative traces and statistical analysis of total traces from six independent experiments of deslanoside-induced bidirectional regulation on the contractility of JSMF in eight high contractile states (HCS). The median value of contractile amplitude of JSMF in normal contractile state is set to 100%, normal contractile state (NCS, control). Low and high contractile states of JSMF are the relative values compared with NCS. Data are expressed as the mean ± SE (%NCS, n = 6); ^bP < 0.01 vs the control; ^dP < 0.01 vs contractile amplitude of JSMF in LCS or HCS before deslanoside administration. CP: Constipation-prominent rats; DP: Diarrhea-prominent rats: SNP: Sodium nitroprusside; Ach: Acetylcholine.