Several factors including ITPA polymorphism influence ribavirin-induced anemia in chronic hepatitis C

Figure 3 Receiver operating characteristic curves generated with every cut-off point of predicted probability of significant hemoglobin decline (> 3. 0 g/dL at week 4 of treatment) corresponding to each hemoglobin decline from baseline at week 2 of treatment. The area under the curve was 0.913 (95% confidence interval: 0.885-0.941, P = 4.08 × 10^-43). When the sensitivity and false-positive rate were 0.844 and 0.131, the Youden’s index value of 0.713 was maximal. The optimal cut-off point of hemoglobin decline at 2 wk was 1.45 g/dL.