Several factors including ITPA polymorphism influence ribavirin-induced anemia in chronic hepatitis C

Table 3 Pretreatment variables influencing significant hemoglobin decline in the derivation group

Variable	P value		OR (95% CI)
	Univariate analysis	Multivariate analysis
Age (yr)	0.110
Sex (female vs male)	0.0163
Weight (kg)	5.18 × 10-3
BMI	5.93 × 10-3
Height (cm)	0.153
BSA (m2)	0.0139
ALT (IU/L)	0.114
GGT (IU/L)	0.118
Albumin (g/dL)	6.88 × 10-3
Creatinine (mg/dL)	4.71 × 10-4
WBC count (× 103/mL)	0.147
Hemoglobin (g/dL)	7.75 × 10-8	1.29 × 10-9	1.89 (1.54-2.32)
Platelet count (× 104/mL)	0.558
Ccr (mL/min)	0.140
GFR (mL/min/1.73 m2)	5.69 × 10-4	6.46 × 10-4	0.959 (0.942-0.977)
CL/F (L/h)	0.814
Stage of fibrosis	0.641
Grade of inflammation	0.570
rs1127354 (CC vs CA/AA)	8.04 × 10-10	1.60 × 10-7	28.26 (8.10-98.62)
rs6051702 (AA vs AC/CC)	0.372
RBV dosage (mg/kg/d)	0.419
Peg-IFN α (2a vs 2b)	0.360
Viral load (log10 IU/mL)	0.355

BMI: Body mass index; BSA: Body surface area; ALT: Alanine transaminase; GGT: γ glutamyl transpeptidase; WBC: White blood cell; GFR: Glomerular filtration rate; SNP: Single nucleotide polymorphism; Peg-IFN: Pegylated interferon; OR: Odds ratio; CI: Confidence interval.