Effects and mechanisms of store-operated calcium channel blockade on hepatic ischemia-reperfusion injury in rats

Figure 2 Store-operated calcium channel blockers inhibit Ca²⁺ oscillations of freshly isolated hepatocytes. A: Ca²⁺ stores were depleted with 4 μmol/L thapsigargin (TG), causing two peaks, the first being Ca²⁺ released from endoplasmic reticulum (ER), and the second peak being Ca²⁺ entry through the plasma membrane (n = 16); B: 10 μmol/L SKF-96365 inhibited Ca²⁺ oscillations (n = 12); C: 25 μmol/L U73122 inhibited Ca²⁺ oscillations (n = 10); D: 100 μmol/L tetrandrine inhibited Ca²⁺ oscillations (n = 10).