Adenovirus-expressed preS2 antibody inhibits hepatitis B virus infection and hepatic carcinogenesis

Figure 3 Ad315-preS2Ab effectively inhibited diethylnitrosamine-induced hepatic cirrhosis and carcinogenesis in hepatitis B virus transgenic mice. A: Ad315-preS2Ab-mediated preS2Ab expression demonstrates significant inhibitory effects against diethylnitrosamine-induced hepatic cirrhosis and carcinogenesis in HBV transgenic mice, as shown by significantly fewer (left panel) and smaller cancerous nodes (right panel) (P < 0.05); B: Pathological findings show that animals in the Ad315-preS2Ab group have a lesser degree of cirrhosis (upper panel, HE, × 100; arrows: proliferated fibrous septa) as well as fewer and smaller cancerous nodes (lower panel, HE, ×100; arrows: cancerous nodes) compared with the two control groups. HBV: Hepatitis B virus; HE: Hematoxylin and eosin. DEN: Diethylnitrosamine.