8-Hydroxydeoxyguanosine: Not mere biomarker for oxidative stress, but remedy for oxidative stress-implicated gastrointestinal diseases

Figure 1 Antitumorigenic action of exogenous 8-hydroxydeoxyguanosine on Helicobacter pylori-induced gastric tumorigenesis. Helicobacter pylori (H. pylori) infection with additional administration of high-salt diet resulted in gastric tumorigenesis in interleukin-10 knockout mice. Continuous administration of exogenous 8-hydroxydeoxyguanosine (8-OHdG) led to significant prevention of H. pylori-induced gastric tumorigenesis as well as amelioration of gastritis. H. pylori infection followed with high-salt diet resulted in significant tumorigenesis as well as atrophic changes in gastric mucosa, whereas the gastric mucosa co-treated with 8-OHdG was free from tumorigenesis or atrophic changes.