No association between IRF3 polymorphism and susceptibility to hepatitis B virus infection in Chinese patients

doi:10.3748/wjg.v18.i4.388

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Jan 28, 2012 (publication date) through Nov 24, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jan 28, 2012; 18(4): 388-392
Published online Jan 28, 2012. doi: 10.3748/wjg.v18.i4.388

Table 1 Genotype and allele distributions of interferon regulatory factors tag single nucleotide polymorphisms in patients with chronic hepatitis B virus infection and with self-limiting hepatitis B virus infection n (%)

IRF3	Chronic HBV infection	Acute HBV infection	P value	OR (95% CI)
rs10415576	n = 985	n = 294
AA	347 (35.23)	119 (40.48)		1.0
GG	135 (13.71)	33 (11.22)	0.125	1.4029 (0.9091-2.1650)
AG	503 (51.07)	142 (48.30)	0.172	1.2148 (0.9187-1.6063)
A	1197 (60.76)	380 (64.63)	0.091	1.1798 (0.9740-1.4291)
G	773 (39.24)	208 (35.37)
rs2304204	n = 985	n = 294
AA	542 (55.03)	166 (56.46)
GG	54 (5.48)	14 (4.76)	0.594	1.1813 (0.6400-2.1807)
AG	389 (39.49)	114 (38.78)	0.75	1.0451 (0.7965-1.3713)
A	1473 (74.77)	446 (75.85)	0.596	1.0579 (0.8552-1.3133)
G	497 (25.23)	142 (24.15)
rs2304206	n = 985	n = 294
CC	639 (64.87)	191 (64.97)		1.0
TT	30 (3.05)	7 (2.38)	0.562	1.2810 (0.5539-2.9627)
CT	316 (32.08)	96 (32.65)	0.909	0.9839 (0.7437-1.3016)
C	1594 (80.91)	478 (81.29)	0.837	1.0250 (0.8097-1.2976)
T	376 (19.09)	110 (18.71)	0.837	1.0250 (0.8097-1.2976)

IRF3: Interferon regulatory factors 3. HBV: Hepatitis B virus; OR: Odds ratio; CI: Confidence interval.

Citation: Yan F, Gao YF, Lv F, Zhang TC, Li X, Yin HF. No association between IRF3 polymorphism and susceptibility to hepatitis B virus infection in Chinese patients. World J Gastroenterol 2012; 18(4): 388-392
URL: https://www.wjgnet.com/1007-9327/full/v18/i4/388.htm
DOI: https://dx.doi.org/10.3748/wjg.v18.i4.388