α-fetoprotein, vascular endothelial growth factor receptor-1 and early recurrence of hepatoma

Table 4 Multivariate analyses of variables that are predictive of early hepatocellular carcinoma recurrence after curative hepatectomy

	P value	Risk ratio	95% CI
Age ≤ 60 yr	0.0899	3.147	0.836-11.838
HBsAg +	0.3601	1.821	0.504-6.571
Albumin ≤ 4.0 mg/dL	0.0038	6.536	1.832-23.256
AFP > 200 ng/nL	0.2571	2.330	0.539-10.067
AFPL3 ≤ 15%	0.4379	1.869	0.385-9.090
PIVKA-II > 40 mAU/mL	0.1494	2.959	0.677-12.987
Tumor number solitary	0.9127	1.088	0.240-4.938
Tumor size > 3 cm	0.1177	3.026	0.756-12.114
vp positive	0.0069	6.639	1.681-26.219
vv positive	0.2221	0.234	0.023-2.408
im positive	0.2307	2.508	0.557-11.289
BM AFP mRNA: positive	0.0761	2.704	0.901-8.113

CI: Confidence interval; BM: Bone marrow; AFP: α-fetoprotein; HBsAg: Hepatitis B surface antigen; vp: Microscopic tumor thrombus in the portal vein; vv: Microscopic tumor thrombus in the hepatic vein; im: Microscopic intrahepatic metastasis.