Nitroglycerine effects on portal vein mechanics and oxidative stress in portal hypertension

Table 2 Haemodynamic and biomechanical parameters of portal vein before and after nitroglycerine administration

Parameters	Groups	0 min	P value	10 min	P value	15 min	P value
D (mm)	Patients	11.60 ± 0.32	< 0.01	13.81 ± 0.31b	< 0.01	13.63 ± 0.33b	< 0.01
	Controls	9.19 ± 0.33		11.02 ± 0.34b		11.72 ± 0.37b
CSA (cm2)	Patients	1.08 ± 0.06	< 0.01	1.52 ± 0.69b	< 0.01	1.49 ± 0.70b	< 0.01
	Controls	0.68 ± 0.05		1.09 ± 0.06b		1.11 ± 0.06b
Q (l/min)	Patients	0.61 ± 0.05	NS	0.80 ± 0.07b	NS	0.78 ± 0.71b	< 0.05
	Controls	0.66 ± 0.06		0.86 ± 0.05b		0.95 ± 0.08b
Sr (1/s)	Patients	66.50 ± 3.91	< 0.01	49.85 ± 3.07b	< 0.01	51.71 ± 3.30b	< 0.01
	Controls	139.87 ± 5.25		111.29 ± 5.57b		83.83 ± 5.58b
Vmean (cm/s)	Patients	9.39 ± 0.50	< 0.01	8.55 ± 0.55a	< 0.01	8.69 ± 0.57	< 0.01
	Controls	15.63 ± 0.48		13.13 ± 0.44b		14.34 ± 0.54b
Vmax (cm/s)	Patients	10.60 ± 0.57	< 0.01	9.77 ± 0.65b	< 0.01	9.84 ± 0.62b	< 0.01
	Controls	19.31 ± 0.56		16.51 ± 0.51b		18.03 ± 0.69b
Vmin (cm/s)	Patients	8.18 ± 0.43	< 0.01	7.34 ± 0.48b	< 0.01	7.53 ± 0.53b	< 0.01
	Controls	11.96 ± 0.48		9.75 ± 0.46b		10.65 ± 0.47b
RI	Patients	0.22 ± 0.01	< 0.01	0.24 ± 0.01	< 0.01	0.24 ± 0.01	< 0.01
	Controls	0.37 ± 0.02		0.41 ± 0.02		0.40 ± 0.01
L (cm)	Patients	13.69 ± 1.12	NS	17.95 ± 1.68b	NS	17.52 ± 1.58b	NS
	Controls	15.08 ± 1.56		17.00 ± 1.56a		21.26 ± 1.78b
Fideal	Patients	/	/	2.32 ± 0.21d	NS	2.11 ± 0.17d	< 0.05
	Controls	/		2.54 ± 0.34d		3.38 ± 0.51d
ΔPratio	Patients	/	/	0.66 ± 0.03	NS	0.68 ± 0.03	< 0.05
	Controls	/		0.68 ± 0.04		0.49 ± 0.04
F	Patients	/	/	1.34 ± 0.07	NS	1.31 ± 0.06	NS
	Controls	/		1.45 ± 0.10		1.48 ± 0.08
ΔP (mmHg)	Patients	/	/	0.004 ± 0.003	< 0.01	0.005 ± 0.003	< 0.05
	Controls	/		0.029 ± 0.006		0.014 ± 0.003e

Values are expressed as mean ± SE; P in colon 3, 5 and 7 relates to the existance of the difference between groups, while a and b represent the existance of difference between the initial measurement and the measurement in 10th or 15th min. d represents the existance of difference between F_ideal and F. e represents the existance of difference between the measurements in 10th and 15th min.

^aP < 0.05 vs 0 min,

^bP< 0.01 vs 0 min,

^dP < 0.01 vs F,

^eP < 0.05 vs 10 min. D: Portal diameter; CSA: Cross sectional area; Q: ; Sr: Shear rate; RI: Portal resistance index; L: Length; F_ideal: Expected (ideal) portal vein flow ratio; F: Portal vein flow ratio; ΔP_ratio: Pressure ratio; ΔP: Pressure difference; NS: Not significant.