Nitroglycerine effects on portal vein mechanics and oxidative stress in portal hypertension

Table 1 Demographic and clinical characteristics of investigated groups n (%)

Clinical parameters	Patients(n = 39)	Control(n = 30)	P value
Average age (yr) (mean ± SE)	54.8 ± 1.3	42.5 ± 0.9	< 0.01
Gender
Male	34 (87.1)	17 (56.7)	< 0.01
Female	5 (12.9)	13 (43.3)	< 0.01
Body mass (kg ± SE)	72.5 ± 2.0	72.8 ± 2.6	NS
Height (cm ± SEM)	170.4 ± 1.4	171.1 ± 2.1	NS
Body mass index (mean ± SE)	41.9 ± 1.2	42.3 ± 1.3	NS
Diagnosis			< 0.01
Cirrhosis hepatis	38 (97.4)	0 (0)
Hepatitis B	1 (2.6)	0 (0)
Diameter liver (mm ± SE)	168.4 ± 3.1	147.3 ± 2.2	< 0.01
Ascites			< 0.01
Yes	4 (10.3)	0 (0)
No	35 (89.7)	30 (100)
Varices esophagi			< 0.01
Yes (Grade III)	3 (7.7)	0 (0)
No	36 (92.3)	30 (100)
AST (U/I ± SEM)	90.5 ± 15.5	21.4 ± 1.4	< 0.01
ALT (U/I ± SEM)	45.3 ± 8.6	24.1 ± 1.5	< 0.01
GGT (U/I ± SEM)	267.5 ± 41.6	35.6 ± 1.6	< 0.01
AST			< 0.01
Increased	25 (64.1)	0 (0)
Normal	14 (35.9)	30 (100)
ALT			< 0.01
Increased	12 (30.7)	0 (0)
Normal	27 (69.3)	30 (100)
GGT			< 0.01
Increased	22 (56.4)	0 (0)
Normal	17 (43.6)	30 (100)
Total bilirubin (μmol/L ± SE)	43.3 ± 8.0	18.6 ± 0.8	< 0.01
Direct bilirubin (μmol/L ± SE)	18.2 ± 3.9	2.9 ± 0.2	< 0.01
Total bilirubin			< 0.01
Increased	25 (64.1)	0 (0)
Normal	14 (35.9)	30 (100)
Direct bilirubin			< 0.01
Increased	29 (74.4)	0 (0)
Normal	10 (25.6)	30 (100)

AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; GGT: Gamma glutamyltransferase; NS: Not significant.