MUC5AC/β-catenin expression and KRAS gene alteration in laterally spreading colorectal tumors

Figure 6 Alterations of expression of mucin core protein, p53 and β-catenin, cell proliferation and v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog mutations in malignant transformation of laterally spreading tumors. Large arrow: Marked upregulation; Medium arrow: Moderate upregulation; Small arrow: Mild upregulation; ++: Frequently mutated; +: Infrequently mutated; -: Not mutated; LGD: Adenoma with low grade dysplasia; HGD: Adenoma with high grade dysplasia; INV: Adenocarcinoma invading into submucosa; KRAS: v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog; Gr: Granular; NGr: Non-granular.