MUC5AC/β-catenin expression and KRAS gene alteration in laterally spreading colorectal tumors

Figure 3 Immunoreactive scores for p53 (A) and nuclear β-catenin (B), and labeling indices for Ki-67 in the lower zone (C) in all laterally spreading tumors. Gr, Gr-LST (black bar); NGr, NGr-LST (white bar); LSTs: laterally spreading tumors. Data are mean ± SD; ^{a, c, e}P < 0.05, p53: Gr-HGD vs Gr-INV; nuclear β-catenin: Gr-type vs NGr-type; Ki-67, Gr-type vs NGr-type; ^{b, d, f, h, j, l, n}P < 0.01, p53: NGr-LGD vs NGr-INV; Gr-LGD vs Gr-HGD or Gr-INV; nuclear β-catenin: Gr-LGD vs Gr-HGD or Gr-INV: Gr-LGD vs NGr-LGD; Ki-67, Gr-LGD vs NGr-INV. IRSs: Immunoreactive scores; LGD: Adenoma with low grade dysplasia; HGD: Adenoma with high grade dysplasia; INV: Adenocarcinoma invading into submucosa; Gr: Granular; NGr: Non-granular; LI: Labeling indice.