Dietary copper triggers onset of fulminant hepatitis in the Long-Evans cinnamon rat model

Figure 6 Liver gene expression of Long-Evans cinnamon rat is significantly altered after high copper regimen. Relative expression of individual mRNA in Long-Evans cinnamon (LEC) rats (n = 7) that were subjected to early high copper (hCu) regimen (left boxes) and in age-matched LEC rats (n = 5) receiving reduced copper (rCu) (right boxes). Animals were analyzed at fulminant hepatitis. Fold-change was calculated within groups by the Δct method using the HPRT gene for normalization. Data are shown as a box plot representation as calculated from three independent experiments. Numbers refer to difference of fold-change with regard to the median of each group.