Biochemical characteristics of neonatal cholestasis induced by citrin deficiency

Table 2 Comparison of birth weight, biochemical indices and their ratios among the three groups

	Reference range and unit	BA (n = 39)		INC (n = 39)		NICCD (n = 32)
		Median	Inter-quartile	Median	Inter-quartile	Median	Inter-quartile
Birth weight	2.5-4.0 kg	3.2	2.9-3.8	3.1	2.8-3.5	2.9	2.4-3.4
Biochemical indices
T-Bilac	2-20 mmol/L	159.5	140.2-201.4	133.8	90.0-190.4	112.7	64.4-165.4
D-Bilace	0-6 mmol/L	134	115.9-151.2	87.3	63.0-123.6	59.6	43.1-90.9
ALTce	< 40 IU/L	108	62.0-199.0	84.5	46.0-166.0	34	23.0-55.0
ASTce	< 40 IU/L	153	115.0-239.0	130.5	81.0-223.0	74	53.5-150.0
GGTac	< 50 IU/L	558	300.0-1086.0	155	91.0-294.0	187.5	136.0-253.0
TBAce	< 40 mmol/L	112	84.9-153.9	103	70.9-135.3	177.9	111.2-236.4
Total proteince	55-78 g/L	57.4	55.3-63.1	57.2	52.5-62.8	48.5	44.5-53.9
Albumince	35-55 g/L	38.4	36.3-42.2	39.9	37.0-42.3	34.9	30.7-38.2
Glucosece	3.9-5.9 mmol/L	4.1	3.4-5.1	4	3.4-4.6	3.2	2.0-4.4
TCHce	3.12-5.20 mmol/L	4.57	3.81-5.26	4	3.24-4.74	3.33	2.97-4.00
Ratios
D-Bil/T-Bilace		0.77	0.72-0.81	0.74	0.59-0.80	0.54	0.40-0.74
AST/ALTce		1.38	0.94-1.97	1.48	1.10-2.66	2.46	1.95-3.63
TBA/D-Bilace		0.85	0.72-1.09	1.04	0.92-1.14	3.36	1.98-4.43
D-Bil/TCHac		30.2	22.8-34.0	21.5	16.7-31.2	18.7	13.9-26.6
TBA/TCHce		24.7	19.8-30.2	24.2	21.4-26.9	60.7	32.4-70.9

^aP < 0.05 between BA and INC;

^cP < 0.05 between BA and NICCD;

^eP < 0.05 between INC and NICCD. NICCD: Neonatal intrahepatic cholestasis caused by citrin deficiency; BA: Biliary atresia; INC: Idiopathic neonatal cholestasis; TBA: Total bile acid; T-Bil: Total bilirubin; D-Bil: Direct bilirubin; AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; GGT: γ-glutamyltranspeptidase; TCH: Total cholesterol.