MUC5AC/&beta;-catenin expression and KRAS gene alteration in laterally spreading colorectal tumors

doi:10.3748/wjg.v18.i39.5551

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Oct 21, 2012 (publication date) through Nov 28, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Oct 21, 2012; 18(39): 5551-5559
Published online Oct 21, 2012. doi: 10.3748/wjg.v18.i39.5551

Table 3 Frequency of KRAS and BRAF mutations in laterally spreading tumor of the colorectum

Type of tumors	Number (%) of mutated samples
	All			Proximal colon
	n	KRAS	BRAF	n	KRAS
Gr-type	29	15 (52)^a	2 (7)	13	9 (69)^c
LGD	10	6 (60)	0 (0)	7	6 (86)^d,e
HGD	10	6 (60)^b	1 (10)	3	2 (67)
INV	9	3 (33)	1 (11)	3	1 (33)
NGr-type	27	2 (7)^a	0 (0)	18	1 (6)^c
LGD	10	1 (10)	0 (0)	8	1 (13)^d
HGD	10	0 (0)^b	0 (0)	8	0 (0)
INV	7	1 (14)	0 (0)	2	0 (0)
Total	56	17 (30)	2 (4)	30	10 (33)

Gr-type: Granular type of laterally spreading tumor; NGr-type: Flat- or non-granular type of laterally spreading tumor; LGD: Adenoma with low grade dysplasia; HGD: Adenoma with high grade dysplasia; INV: Adenocarcinoma invading submucosa; KRAS: v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog; BRAF: v-raf murine sarcoma viral oncogene homologue B1. ^{a, c, e}P < 0.05, All and proximal colon: Gr-type vs NGr-type; Gr-LGD: proximal vs distal colon; ^{b, d}P < 0.01, all and proximal colon: Gr-HGD vs NGr-HGD; proximal colon: Gr-type vs NGr-type.

Citation: Nakae K, Mitomi H, Saito T, Takahashi M, Morimoto T, Hidaka Y, Sakamoto N, Yao T, Watanabe S. MUC5AC/β-catenin expression and KRAS gene alteration in laterally spreading colorectal tumors. World J Gastroenterol 2012; 18(39): 5551-5559
URL: https://www.wjgnet.com/1007-9327/full/v18/i39/5551.htm
DOI: https://dx.doi.org/10.3748/wjg.v18.i39.5551