Oxaliplatin-induced severe anaphylactic reactions in metastatic colorectal cancer: Case series analysis

Table 2 Studies on severe anaphylactic reactions following oxaliplatin, including data published from 1997 to 2012 in English (24 studies, n = 66)

Ref.	Published year/region	Patient No.	Age (yr)	Male/female	Previous oxaliplatin cycles	Oxaliplatin dose (mg/m2)	Presenting symptoms	Onset time after oxaliplatin infusion	Outcome
de Gramont et al[10]	1997/France	5	NA	NA	NA	NA	NA	NA	Recovery
Tournigand et al[11]	1998/France	5	59-77	3/2	5-12	85-100	Reduced blood pressure, flushing, headache, tachycardia, respiratory distress	Immediate	Recovery
Larzillière et al[12]	1999/France	1	55	1/0	5	85	Flushing, profuse sweats, arterial hypertension, tachycardia	30 min	Recovery
Médioni et al[13]	1999/France	1	63	1/0	6	100	Visual disturbances, edema, tachycardia, severe hypotension, anaphylactic shock	Immediate	Recovery
Sørbye et al[14]	2000/Norway	1	40, 52	1/0	8	85	Severe thrombocytopenia	Immediate	Recovery
Santini et al[15]	2001/Italy	1	52	1/0	6	60	Chills, fever, nausea, vomiting, crampy abdominal pain, diarrhea, hypotension	15 min	Recovery
Schüll et al[16]	2001/Austria	1	54	1/0	5	85	Flush, generalised erythema of the trunk, nausea, hypotension	30 min	Recovery
Brandi et al[17]	2003/Italy	9	NA	NA	2-17	NA	Dyspnea, laryngospasm, agitation, tachycardia, precordial pain, erythema, sweating	NA	Recovery
Thomas et al[18]	2003/United States	1	50	0/1	9	NA	Fever, respiratory distress	2 h	Recovery
Lenz et al[19]	2003/Germany	2	NA	NA	NA	85	Severe abdominal, chest pain.	Immediate	Recovery
Bhargava et al[20]	2004/United States	1	50	0/1	12	NA	Palpitation, flushing, hypotensive, wheezing	15 min	Recovery
González-Mahave et al[21]	2005/Spain	2	43, 44	1/1	4, 11	NA	Respiratory collapse, fever	Immediate	Recovery
Maindrault-Goebel et al[22]	2005/France	3	NA	NA	NA	NA	Anaphylactic shock	NA	Recovery
Siu et al[8]	2006/Hong Kong	2	NA	NA	NA	100	Hypotension, oxygen desaturatio, full-blown anaphylactic reactions	NA	NA
Tze et al[23]	2006/China	1	60	0/1	12	NA	Anaphylactic shock	Immediate	Recovery
Lee et al[24]	2006/Taiwan	4	36-74	NA	6-7	85-100	Anaphylactic shock, hypertensive crisis	5-50 min	Recovery
Yanqi et al[25]	2007/China	1	52	1/0	6	150 mg	Anaphylactic shock	10 min	Recovery
Santodirocco et al[26]	2008/Italy	1	44	0/1	14	85	Acute thrombocytopenia, hemolysis, bleeding	1 h	Recovery
Shao et al[27]	2008/Taiwan	1	64	1/0	23	NA	Thrombocytopenia	1 h	Fatal
Chay et al[9]	2010/Singapore	11	36-75	4/7	NA	NA	Respiratory collapse, flushing, hypokalemia	NA	Recovery
Pietrantonio et al[28]	2010/Italy	1	NA	NA	NA	NA	Acute thrombocytopenia	NA	Recovery
Potenza et al[29]	2010/Italy	1	46	1/0	6	85	Respiratory collapse	10 h	Recovery
Teng et al[30]	2011/Taiwan	1	78	1/0	17	85	Pancytopenia, coagulopathy, intracranial hemorrhage	30 min	Fatal
Wang et al, this study	2012/Taiwan	7	36-72	3/4	5-29	85-90	Consciousness loss, chest tightness, cold sweating, nausea, vomiting, shock	immediately to 2 h	1 fatal

NA: Not applicable.