Oxaliplatin-induced severe anaphylactic reactions in metastatic colorectal cancer: Case series analysis

Table 1 Clinical characteristics of patients with life-threatening severe anaphylactic reactions following oxaliplatin chemotherapy (n = 8)

Patient	Sex	Age (yr)	Allergy history	Primary CRC site	TNM classification	Stage	Previous chemotherapy regimens	Previous oxaliplatin chemotherapy cycles	Oxaliplatin dose (mg/m2)	Tumor response	Presenting symptoms	Onset time	Outcome	Rechallenge
1	F	50	Alcohol	Rectum	T4N0M1	IV	FOLFIRI x12, FOLFOX x10	10	85	SD	Consciousness loss, dizziness, shock	30 min	Recovery	No
2	M	71	Nil	Rectum	T2N1M1	IV	FOLFOX x12, FOLFIRI + Bevacizumabx12, FOLFOX x1	13	85	PD	Consciousness loss, shock	20 min	Fatal	No
3	M	36	Nil	Sigmoid colon	T4N2M1	IV	FOLFIRI x13, FOLFOX + Bevacizumab x5, FOLFIRI + Cetuximab x5, FOLFOX x7	12	90	PD	Consciousness loss, respiratory distress, cold sweating	Immediate	Recovery	Yes
4	F	57	Nil	Sigmoid colon	T1N0M1	IV	FOLFIRI x5, FOLFOX x7, FOLFIRI + Bevacizumabx18, FOLFOX + Bevacizumab x1	8	85	PD	Respiratory distress, cold sweating	2 h	Recovery	No
5	F	68	Nil	Sigmoid colon	T3N2M1	IV	FOLFIRI x12, FOLFOX x8	8	85	SD	Angioedema, slurred speech, respiratory distress	30 m	Recovery	No
6	F	72	Nil	Descending colon	T4N1M1	IV	FOLFIRI x7, FOLFOX x3, FOLFIRI x12, FOLFOX x2	5	85	PD	Nausea, vomiting, shock,	10 min	Recovery	No
7	M	59	Flurbiprofen	Rectum	T3N2M1	IV	FOLFOX x19, FOLFIRI x8, FOLFOX x10	29	85	SD	Consciousness loss, respiratory distress, cold sweating	Immediate	Recovery	No
8	M	62	Nil	Sigmoid colon	T3N1M1	IV	FOLFIRI + Bevacizumabx6, FOLFOX x7	7	85	PD	Consciousness loss, respiratory distress, cold sweating	20 min	Recovery	No

M: Male; F: Female; CRC: Colorectal cancer; TNM: Tumor, nodes, metastasis; PD: Progressive disease; SD: Stable disease; FOLFIRI: Chemotherapy regimen including 5-fluorouracil, leucovorin, irinotecan; FOLFOX: Chemotherapy regimen including 5-fluorouracil, leucovorin, oxaliplatin.