Hepatitis B virus pre-S2 start codon mutations in Indonesian liver disease patients

doi:10.3748/wjg.v18.i38.5418

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Oct 14, 2012; 18(38): 5418-5426
Published online Oct 14, 2012. doi: 10.3748/wjg.v18.i38.5418

Table 1 Demographic data and the prevalence of pre-S mutations associated with progressive liver disease

	AC	CH	LC	HCC	All	P value (all)	P value (AC-CH vs LC)	P value (AC-CH vs HCC)
n (%)	73 (27.2)	66 (24.6)	66 (24.6)	63 (23.5)	268 (100.0)	-	-	-
Gender, n (%)
Male	69 (94.5)	49 (74.2)	46 (69.7)	49 (77.7)	213 (79.5)	0.002	0.027	0.314
Female	4 (5.5)	17 (25.8)	20 (30.3)	14 (22.2)	55 (20.5)
Age (yr, mean ± SD)	32.3 ± 9.1	41.9 ± 13.3	50.1 ± 10.9	48.6 ± 11.6	42.9 ± 13.3	< 0.001	< 0.001	< 0.001
Genotype, n (%)
B	56 (76.7)	46 (69.7)	46 (69.7)	52 (82.5)	200 (74.6)	0.267	0.453	0.393
C	17 (23.3)	20 (30.3)	20 (30.3)	11 (17.5)	68 (25.4)
HBeAg¹
HBeAg(+)	13 (22.0)	36 (56.3)	18 (30.5)	15 (28.3)	82 (34.9)	< 0.001	0.222	0.144
HBeAg(-)	46 (78.0)	28 (43.8)	41 (69.5)	38 (71.7)	153 (65.1)
Mutation
M120	2 (2.7)	12 (18.2)	27 (40.9)	18 (28.6)	59 (22.0)	< 0.001	< 0.001	0.002
T130	8 (11.0)	19 (28.8)	18 (27.3)	25 (39.7)	70 (26.1)	0.0018	0.311	0.054
Q132	11 (15.1)	19 (28.8)	21 (31.8)	26 (41.3)	77 (28.7)	0.008	0.111	0.04
A138	10 (13.7)	21 (31.8)	22 (33.3)	26 (41.3)	79 (29.5)	0.003	0.089	0.094

¹Number of samples for HBeAg. n (all) = 235, n (AC:CH:LC:HCC) = 59:64:59:53. AC: Asymptomatic carrier; CH: Chronic hepatitis; LC: Liver cirrhosis; HCC: Hepatocellular carcinoma; HBeAg: Hepatitis B e antigen.

Citation: Utama A, Siburian MD, Fanany I, Intan MDB, Dhenni R, Kurniasih TS, Lelosutan SA, Achwan WA, Zubir N, Arnelis, Lukito B, Yusuf I, Lesmana LA, Sulaiman A. Hepatitis B virus pre-S2 start codon mutations in Indonesian liver disease patients. World J Gastroenterol 2012; 18(38): 5418-5426
URL: https://www.wjgnet.com/1007-9327/full/v18/i38/5418.htm
DOI: https://dx.doi.org/10.3748/wjg.v18.i38.5418